We provide early predictive insights to help pharmaceutical companies meet regulatory requirements and accelerate the development of safe and effective drugs.
- Quantitative Proteomics Services
- Supported Sample Types
- Use Case Applications
- Custom Solutions & Support
High-precision protein measurement using targeted mass spectrometry
- Quantify proteins in complex matrices with femtomole–attomole sensitivity
- Small sample volumes: 5 mg tissue and 50,000 cells
- Multiplexed analysis of 3,000–7,000 proteins
- Robust and validated protocols for consistent accuracy
Compatibility across biological sample formats
- Cell cultures
- Tissues
- Biofluids (plasma, blood, CSF, urine)
Supporting drug discovery, IVIVE/PBPK modeling, and translational research
- Confirm protein levels in an induction assay
- Characterize in vitro reagents for protein levels for accurate IVIVE and PBPK modeling
- Confirm protein levels in inhouse generated recombinant proteins as compared to relevant in vivo levels
- Interspecies differences in protein levels
- Interindividual variability in protein levels, i.e., effect of age, genotype, sex, disease state/conditions
- Global proteomics analysis to evaluate molecular perturbations in biological pathways
Tailored proteomics solutions to meet your research goals
- Method development for quantification of any protein or set of proteins
- Selection of surrogate peptides for targeted proteomics analysis
- Custom synthesis of surrogate peptide kits for protein quantification
- Custom support, consulting, and training
Our Process
Partners
Applications
Characterized in vitro reagents
Utilizing quantitative proteomics, we can characterize your in vitro reagents for absolute protein levels. Precisely characterized in vitro reagents and animal models can help you avoid inaccurate IVIVE and misinterpretation of preclinical data.
Global Proteomics
Quantification of nearly all proteins (3000-7000 proteins) in a sample using global proteomics methods.
Targeted Proteomics
Quantification of drug metabolizing enzymes, transporters, and drug receptors using targeted proteomics. Our technology can quantify proteins including transmembrane proteins in complex matrices such as cell homogenate, tissues, and biofluids at femtomole levels in humans as well as preclinical species.
Custom Consultation
We can answer your questions on how to use of protein abundance and activity data for physiologically-based pharmacokinetic or pharmacodynamic models.
At Precision Quantomics, we align our testing services with the latest regulatory guidelines, including the FDA Modernization Act 2.0 (sometimes referred to as “FDA 2.0”) and the Critical Path Initiative, fostering research to identify novel biomarkers. Our tests are designed to assess both markers currently required and those likely to become recommended for the approval of new drugs, helping pharmaceutical companies prepare to meet regulatory requirements and accelerate the development of safe and effective therapies.
Take Your Drug Metabolism Research To The Next Level with Precision Quantomics, Inc.
For more information and to place an order, contact our sales team!